LUMPY SKIN DISEASE VIRUS: APPROACHES TO ATTENUATION FOR VACCINE DEVELOPMENT

Genome of lumpy skin disease virus.

Lumpy skin disease virus (LSDV), a member of the capripoxvirus genus of the Poxviridae, is the etiologic agent of an important disease of cattle in Africa. Here we report the genomic sequence of LSDV. The 151-kbp LSDV genome consists of a central coding region bounded by identical 2.4 kbp-inverted terminal repeats and contains 156 putative genes. Comparison of LSDV with chordopoxviruses of othe...

Evaluation of Humoral and Cell-mediated Immunity of Two Capripoxvirus Vaccine Strains against Lumpy Skin Disease Virus

Background and Aims: Prevention of Lumpy skin disease (LSD) in cattle is heavily dependent on vaccination. Since the genetic structure of LSD virus has the close relatedness with other Capri-pox virus (CaPV). Therefore, the use of vaccine strains of CaPV derived from sheep and goat would be useful to protect cattle against LSD. Materials and Methods: The susceptible calves of dairy farms were ...

Lumpy Skin Disease

Lumpy skin disease is a poxviral disease with significant morbidity in cattle. Although the mortality rate is generally low, economic losses result from loss of condition, decreased milk production, abortions, infertility and damaged hides. The causative virus seems to be spread mainly by insects, and outbreaks can be widespread and difficult to control. Lumpy skin disease was confined to Afric...

Lumpy Skin Disease

Lumpy skin disease (LSD, knopvelsiekte) is a pox disease of cattle characterised by fever, nodules 4 on the skin, mucous membranes and internal organs, emaciation, enlarged lymph nodes, oedema 5 of the skin, and sometimes death. The disease is of economic importance because it causes 6 reduced production, particularly in dairy herds. It also causes damage to the hide. LSD is caused by 7 strains...

Lumpy skin disease